Sodium Hydroxide → HCID 58235963, compound

Participants

Reaction Steps

Benzyl (1S,3R)-3-(4-methylpiperazin-1-yl)cyclohexylcarbamate ((1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonate (30. g, 5.32 mmol, 1.0 eq.) was taken up in toluene (15 ml); a solution of NaOH (0.234 g, 5.852 mmol, 1.1 eq.) in water (15 ml) was added and stirring was carried out for 30 minutes at RT. The reaction mixture was diluted with toluene (15 ml) and the phases were separated. The org. phase was washed with sat. NaCl solution (15 ml), dried over sodium sulfate and concentrated under reduced pressure. Yield: 96% (1.7 g, 5.13 mmol)

Provenance & Evidence