Sodium Hydroxide → HCID 59449242, compound

Participants

Reaction Steps

Benzyl (1S,3R)-3-(4-methylpiperazin-1-yl)cyclohexylcarbamate (2.0 g, 6.0472 mmol, 1.0 eq.) was dissolved in THF (10 ml) and added dropwise at 0° C. to a suspension of LAH (0.345 g, 9.06 mmol, 1.5 eq.) in THF (30 ml). The reaction mixture was then refluxed for 30 minutes. The reaction mixture was subsequently cooled to 0° C., hydrolyzed with 10% NaOH solution (0.35 ml), filtered off and washed with THF (2×50 ml). The filtrate was concentrated under reduced pressure and dried. Yield: 94% (1.2 g, 5.68 mmol)

Provenance & Evidence