HCID 66799276, compound → HCID 66798742, compound

HRID 1193370Notes

Reaction equation

HRID 1193370 reaction equation
[CH2:1]([N:8](C)[CH:9]1[CH2:14][CH2:13][N:12]([C:15]2[CH:16]=[N:17][C:18]([O:21][CH3:22])=[CH:19][CH:20]=2)[CH2:11][CH2:10]1)C1C=CC=CC=1>CO>[CH3:22][O:21][C:18]1[N:17]=[CH:16][C:15]([N:12]2[CH2:11][CH2:10][CH:9]([NH:8][CH3:1])[CH2:14][CH2:13]2)=[CH:20][CH:19]=1

Participants

3

Reactant 1

HCID 66799276HCID 66799276, compound

Product 1

HCID 66798742HCID 66798742, compoundYield 78%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

N-Benzyl-1-(6-methoxypyridin-3-yl)-N-methylpiperidin-4-amine (450 mg, 1.447 mmol, 1.0 eq.) was dissolved in MeOH (6 ml) and degassed with N2. Pd(OH)2 (225 mg, 50%) was then added and hydrogenation was carried out for 3 hours. After monitoring by TLC, the reaction mixture was filtered over Celite and the filtrate was concentrated under reduced pressure and used in the next stage without being purified further. Yield: 78% (250 mg, 1.13 mmol)

Workup

  1. customdegassed with N2
  2. additionPd(OH)2 (225 mg, 50%) was then added
  3. filtrationthe reaction mixture was filtered over Celite
  4. concentrationthe filtrate was concentrated under reduced pressure
  5. customwithout being purified further

Sources & evidence

ORD record
ord-6836e393d5624708a4f6255d109dd50f
Source dataset
uspto-grants-2014_03
Patent number
US08680159B2

Reaction notes

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