反应详情

N-Benzyl-1-(6-methoxypyridin-3-yl)-N-methylpiperidin-4-amine (450 mg, 1.447 mmol, 1.0 eq.) was dissolved in MeOH (6 ml) and degassed with N2. Pd(OH)2 (225 mg, 50%) was then added and hydrogenation was carried out for 3 hours. After monitoring by TLC, the reaction mixture was filtered over Celite and the filtrate was concentrated under reduced pressure and used in the next stage without being purified further. Yield: 78% (250 mg, 1.13 mmol)

1. customdegassed with N2
2. additionPd(OH)2 (225 mg, 50%) was then added
3. filtrationthe reaction mixture was filtered over Celite
4. concentrationthe filtrate was concentrated under reduced pressure
5. customwithout being purified further