反应详情

Benzyl 1-(2-methoxypyridin-4-yl)piperidin-4-yl(methyl)carbamate (250 mg, 0.704 mmol, 1.0 eq.) was dissolved in MeOH (20 ml) and degassed with argon. Pd/C (75 mg) was then added and hydrogenation was carried out for 3 hours. After monitoring by TLC, the reaction mixture was filtered over Celite and washed with MeOH (2×20 ml) and the filtrate was concentrated under reduced pressure. The crude product was used in the next stage without being purified further. Yield: 99% (155 mg, 0.701 mmol)

1. customdegassed with argon
2. additionPd/C (75 mg) was then added
3. filtrationthe reaction mixture was filtered over Celite
4. washwashed with MeOH (2×20 ml)
5. concentrationthe filtrate was concentrated under reduced pressure
6. customwithout being purified further