反应详情

TFA (1 ml) was added dropwise at 0° C. to a solution of (R)-tert-butyl 6-(methyl(1-(pyridin-4-yl)piperidin-4-yl)carbamoyl)-2,3-dihydro-1H-inden-1-ylcarbamate (0.2 g, 0.44 mmol, 1 eq) in dichloromethane (5 ml), and stirring was carried out for 1 h at RT. Then the solvent was concentrated under reduced pressure. The residue was taken up in dichloromethane and concentrated again. Then the TFA salt was stirred for 1 h with Amberlyst-21 in MeOH (10 ml) and filtered. The filtrate was concentrated under reduced pressure and used in the next stage without being purified further.

1. concentrationThen the solvent was concentrated under reduced pressure
2. concentrationconcentrated again
3. stirringThen the TFA salt was stirred for 1 h with Amberlyst-21 in MeOH (10 ml)
4. filtrationfiltered
5. concentrationThe filtrate was concentrated under reduced pressure
6. customwithout being purified further