Potassium Carbonate → HCID 13823795, compound

Participants

Reaction Steps

2.8 g (0.02 mole) of potassium carbonate are added to 3.4 g (0.01 mole) of 1-(2,6-dichloro-4-trifluoromethylphenyl)-4-nitro-5-amino-pyrazole, dissolved in 30 ml of acetonitrile, and 3.7 g (0.022 mole) of methyl α-bromopropionate, dissolved in 10 ml of acetonitrile, are added dropwise at room temperature in the course of 10 minutes. The reaction mixture is heated under reflux for 21/2 hours and filtered hot and the solvent and excess α-bromopropionate are removed by concentration of the filtrate in vacuo. The residue is crystallized from petroleum ether. 3.8 g (88% of theory) of methyl α-{N-[1-(2,6-dichloro-4-trifluoromethyl-phenyl)-4-nitro-pyrazol-5-yl]amino}-propionate of melting point 123° C.-130° C. are obtained.

Provenance & Evidence