Benzene → HCID 70389336, compound

Participants

Reaction Steps

To a solution of 1,2β-methylene-4-hydroxyandrost-4-ene-3,17-dione (0.314 g, 1 mmol) in benzene (10 ml) potassium tert-butoxide (0.224 g, 2 mmol) is added and the mixture heated to reflux for 30 min. After cooling, iodomethane (0.710 g, 5 mmol) is added and the mixture boiled for further 2 hours. Then the organic solution is washed with water, dried and evaporated in vacuum. The flash column chromatography of the residue on silica gel using n-hexane/ethylacetate 60:40 affords 0.246 g (75% yield) of the title compound.

Provenance & Evidence