Ethanol → HCID 21272043, compound

Participants

Reaction Steps

Oxalyl chloride (3.2 g, 2.2 mL, 24.7 mmol) was added dropwise under nitrogen to an ice cold solution of ethyl 7-(phenylmethoxy)-indole (2.3 g, 10.3 mmol) in anhydrous ether (40 mL). The mixture was stirred for 1 hour at room temperature during which time a yellow precipitate was formed. The solvent and the excess of oxalyl chloride was removed at reduced pressure to yield 7-(phenylmethoxy)-indol-3-yl-glyoxyl chloride. Ethanol (50 mL) was then added to the residue and the solution was stirred overnight under nitrogen at room temperature. Removal of the solvent in vacuo provided ethyl 7-(phenylmethoxy)-indol-3-yl-glyoxylate as a tan solid (3 g, 94%).

Provenance & Evidence