(3-Chloropropanesulfonyl)benzene → 1-[3-(1,3-Dimethyl-3,7-dihydro-1H-purine-2,6-dion-7-yl)-2-hydroxypropyl]-4-(3-phenylsulfonylpropyl)piperazine

HRID 1193492Notes

Reaction equation

HRID 1193492 reaction equation
[C:1]1([S:7]([CH2:10][CH2:11][CH2:12]Cl)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:14][N:15]1[C:23](=[O:24])[C:22]2[N:21]([CH2:25][CH:26]([OH:34])[CH2:27][N:28]3[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]3)[CH:20]=[N:19][C:18]=2[N:17]([CH3:35])[C:16]1=[O:36]>>[CH3:14][N:15]1[C:23](=[O:24])[C:22]2[N:21]([CH2:25][CH:26]([OH:34])[CH2:27][N:28]3[CH2:29][CH2:30][N:31]([CH2:12][CH2:11][CH2:10][S:7]([C:1]4[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=4)(=[O:9])=[O:8])[CH2:32][CH2:33]3)[CH:20]=[N:19][C:18]=2[N:17]([CH3:35])[C:16]1=[O:36]

Participants

3

Reactant 2

HCID 11769949(3-Chloropropanesulfonyl)benzene2×HCID 123426891-[3-(1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dion-7-yl)-2-hydroxypropyl]piperazine

Product 1

HCID 144575191-[3-(1,3-Dimethyl-3,7-dihydro-1H-purine-2,6-dion-7-yl)-2-hydroxypropyl]-4-(3-phenylsulfonylpropyl)piperazine

Procedure

In a similar manner, but replacing the 3-phenylsulfonyl-1-chloropropane as needed with other appropriate compounds of Formula 4, the preparation of which is described in Preparation 1, and optionally substituting for the 1-[3-(1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dion-7-yl)-2-hydroxypropyl]piperazine other appropriate compounds of Formula 5, the following compounds of Formula I are obtained:

Workup

  1. customthe preparation of which
  2. customis described in Preparation 1
  3. customthe following compounds of Formula I are obtained

Sources & evidence

ORD record
ord-0804190e2cb84c509cd2e7ee8896294a
Source dataset
uspto-grants-1989_03
Patent number
US04810706

Reaction notes

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