4-Methoxyphenol → HCID 18631234, compound

HRID 1193503Notes

Reaction equation

[CH2:1]([O:8][C:9]([N:11]1[CH2:22][C@H:21]([OH:23])[CH2:20][C@H:12]1[C:13]([N:15]1[CH2:19][CH2:18][CH2:17][CH2:16]1)=[O:14])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:24][O:25][C:26]1[CH:31]=[CH:30][C:29](O)=[CH:28][CH:27]=1>>[CH2:1]([O:8][C:9]([N:11]1[CH2:22][C@@H:21]([O:23][C:29]2[CH:30]=[CH:31][C:26]([O:25][CH3:24])=[CH:27][CH:28]=2)[CH2:20][C@H:12]1[C:13]([N:15]1[CH2:19][CH2:18][CH2:17][CH2:16]1)=[O:14])=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 90154-Methoxyphenol

HCID 18631235HCID 18631235, compound

Product 1

HCID 18631234HCID 18631234, compound

Procedure

By repeating the process of Example 2(a) above but using N-(N-benzyloxycarbonyl-trans-4-hydroxy-L-prolyl)pyrrolidine in place of N-[N-(4-phenylbutanoyl)-trans-4-hydroxy-L-prolyl]pyrrolidine and 4-methoxyphenol in place of phenol, N-[N-benzyloxycarbonyl-cis-4-(4-methoxyphenoxy)-L-prolyl]pyrrolidine (SUAM 14491) was obtained.

Sources & evidence

ORD record: ord-91cda8ed503748fd8dbe7929dc4d9c9a
Source dataset: uspto-grants-1989_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04810721

Reaction notes

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