HCID 21272317, compound → HCID 21272324, compound

HRID 1193515Notes

Reaction equation

HRID 1193515 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([NH:15][C:16]2[CH:20]=[CH:19][N:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[N:17]=2)=[CH:11][CH:10]=1)C1C=CC=CC=1.[H][H]>C(O)C.[Pd]>[C:21]1([N:18]2[CH:19]=[CH:20][C:16]([NH:15][C:12]3[CH:11]=[CH:10][C:9]([OH:8])=[CH:14][CH:13]=3)=[N:17]2)[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1

Participants

5

Reactant 2

HCID 21272317HCID 21272317, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 21272324HCID 21272324, compoundYield 55.7%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A suspension of N-(4-benzyloxyphenyl)-1-phenyl-1-H-pyrazol-3-amine (3.17 g) in ethanol (600 ml) was hydrogenated at atmospheric pressure over 10% palladium on carbon until hydrogen uptake ceased. The reaction mixture was filtered and solvent was evaporated. The resulting solid was recrystallised from ether: petroleum ether to give the title compound (1.3 g) mp 147°-148°.

Workup

  1. filtrationThe reaction mixture was filtered
  2. customsolvent was evaporated
  3. customThe resulting solid was recrystallised from ether

Sources & evidence

ORD record
ord-cb541729c6dd4550ba1e5554a962d55b
Source dataset
uspto-grants-1989_03
Patent number
US04810719

Reaction notes

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