HCID 10725990, compound → 4-(1H-Imidazol-1-yl)pyridine

Participants

Reaction Steps

An ethanolic solution of 5.9 g (0.028 mol) 1,3-dihydro-1-(4-pyridyl)-2H-imidazole-2-thione prepared in Example 8 is charged with 23.0 g Raney nickel and 10 ml concentrated ammonium hydroxide. The black slurry is refluxed for 2 hours, then filtered to remove the nickel catalyst. The ethanol is removed under vacuum and the product is extracted into CH2Cl2 (2×100 ml). Drying (NaSO4) and concentration gives the 1-(4-pyridyl)-1H-imidazole.

Provenance & Evidence