HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(3,5-Difluorophenyl)acrylic acid → 3-(3,5-Difluorophenyl)propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(3,5-Difluorophenyl)acrylic acid | HCID 522810 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 3-(3,5-Difluorophenyl)propionic acid | HCID 3669498 | 99% |
Reaction Steps
A solution of 3-(3,5-difluorophenyl)propenoic acid (0.0435 mol) in tetrahydrofuran (100 ml) and a slurry of 10% palladium on carbon (1.5 g) in ethyl acetate were shaken together under 50 psi hydrogen for 4 hours. The mixture was filtered and concentrated to yield 8 g (99%) of a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04810811 |
| Source dataset | uspto-grants-1989_03 |
| ORD ID | ord-b3e6f6ac2ae54fdeac4eaf42c00d5311 |
| Source note | uspto-grants-1989_03 |