HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → 3-(3,5-Difluorophenyl)propyl Isothiocyanate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Thiophosgene | HCID 10040 | — |
| Reactant | 3-(3,5-Difluorophenyl)propan-1-amine | HCID 14049913 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-(3,5-Difluorophenyl)propyl Isothiocyanate | HCID 14049914 | 55% |
Reaction Steps
A solution of 3-(3,5-difluorophenyl)propylamine (0.0327 mol) and triethylamine (0.072 mol) in tetrahydrofuran (20 ml) was added dropwise to a solution of thiophosgene (0.0392 mol) in tetrahydrofuran at 0°. The reaction was stirred 2 hours at room temperature then ethyl ether was added and the mixture filtered. The filtrate was concentrated and distilled (Kugelrohr) to yield 3.8 g (55%) of a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04810811 |
| Source dataset | uspto-grants-1989_03 |
| ORD ID | ord-2b91444dcacf44ffb40a8e8ff61acae6 |
| Source note | uspto-grants-1989_03 |