L-Aspartic Acid → N-[(3S)-Tetrahydro-2,5-dioxo-3-furanyl]formamide

HRID 1193612Notes

Reaction equation

HRID 1193612 reaction equation
[NH2:1][C@H:2]([C:7]([OH:9])=[O:8])[CH2:3][C:4]([OH:6])=O.[C:10](OC(=O)C)(=[O:12])C>C(O)=O>[CH:10]([NH:1][C@@H:2]1[C:7](=[O:8])[O:9][C:4](=[O:6])[CH2:3]1)=[O:12]

Participants

4

Reactant 2

HCID 5960L-Aspartic AcidHCID 7918Acetic Anhydride

Product 1

HCID 11298025N-[(3S)-Tetrahydro-2,5-dioxo-3-furanyl]formamide

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

A process according to claim 1, wherein said reaction of aspartic acid with formic acid and acetic anhydride to form N-formyl-aspartic anhydride is carried out at a temperature of from 45° to 65° C.

Sources & evidence

ORD record
ord-256736d5ebf34b958d55360729ecd21e
Source dataset
uspto-grants-1989_03
Patent number
US04810816

Reaction notes

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