反应详情

A solution of 31.2 g (0.079 mole) of α,α-bis-(4-fluorophenyl)-1-(phenylmethyl)-4-piperidinemethanol in 400 ml of absolute ethanol was hydrogenated at 50 psi and 70° C. over 5% palladium on carbon over the weekend. The mixture was filtered and the filtrate was concentrated under reduced pressure to give a gum as residue. Methylene chloride was added to the residue and the gum crystallized. The mixture was diluted with petroleum ether and the solid was collected by filtration, washed with petroleum ether, and dried to yield 22 g (92%) of white solid which was recrystallized from isopropyl ether-2-propanol, m.p. 159.5°-160.5° C.

1. filtrationThe mixture was filtered
2. concentrationthe filtrate was concentrated under reduced pressure
3. customto give a gum as residue
4. customthe gum crystallized
5. additionThe mixture was diluted with petroleum ether
6. filtrationthe solid was collected by filtration
7. washwashed with petroleum ether
8. customdried