Hydrogen Bromide → HCID 23036392, compound

Participants

Reaction Steps

A mixture of 69.33 g (0.146 mole) of α,α-bis(4-chlorophenyl)-1-(phenylsulfonyl)-4-piperidinemethanol and 26 g (0.277 mole) of phenol in 400 ml of 48% hydrobromic acid was refluxed for 6 hr and then was stirred at room temperature for 10 hr. The reaction solution was decanted from a gun which had formed in the bottom of the reaction flask. The gum was washed with several portions of water and then was crystallized from ether to give a solid. The solid was recrystallized from a mixture of methanoldiethyl ether to give 26.52 g (43.6%) of white crystalline solid, m.p. 106°-109° C.

Provenance & Evidence