1-Butanol → HCID 23036362, compound

Participants

Reaction Steps

A mixture, 5.83 g (0.02 mole) of 4-[bis(4-fluorophenyl)methyl]piperidine 4.02 g (0.02 mole) of (2-bromoethoxy)benzene and sodium carbonate (3.18 g, 0.03 mole) was heated overnight at gentle reflux in 300 ml of 1-butanol. The reaction was filtered and solvent removed in vacuo. The residue was dissolved in chloroform and extracted with water and 5% sodium hydroxide. Removal of chloroform gave an oil which was converted to the oxalate salt. The salt was recrystallized from methanol-diethyl ether to give 6.0 g (60.3%) of white crystalline product, m.p. 180°-182° C.

Provenance & Evidence