反应详情

A mixture of 3.0 g (0.01 mole) of [α,α-bis(p-fluorophenyl)]-4-piperidinemethanol, 2.0 g (0.01 mole) of 1chloro-4-(3-chloropropoxy)benzene, 5.3 g (0.05 mole) of anhydrous sodium carbonate and 0.3 g of potassium iodide in 100 ml of 1-butanol was refluxed for 20 hr to give, after working up as in Example 1 (recrystallizing the free base from isopropyl alcohol), 1.7 g (36%) of white solid, m.p. 92°-93° C.

1. temperaturewas refluxed for 20 hr
2. customto give
3. customrecrystallizing the free base from isopropyl alcohol), 1.7 g (36%) of white solid, m.p. 92°-93° C.