HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bis(4-fluorophenyl)(piperidin-4-yl)methanol → alpha,alpha-Bis(4-fluorophenyl)-1-[3-(2-methoxyphenoxy)propyl]-4-piperidinemethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bis(4-fluorophenyl)(piperidin-4-yl)methanol | HCID 11208889 | — |
| Reactant | 3-(2-Methoxyphenoxy)propyl chloride | HCID 14715352 | — |
| Catalyst | Potassium Iodide | HCID 4875 | — |
| Product | alpha,alpha-Bis(4-fluorophenyl)-1-[3-(2-methoxyphenoxy)propyl]-4-piperidinemethanol | HCID 14407090 | 66% |
Reaction Steps
Following the procedure of Example 1, [α,α-bis(p-fluorophenyl)]-4-piperidinemethanol and 1-chloro-3-(2-methoxyphenoxy)propane were reacted using in addition potassium iodide catalyst to give the title compound in 66% yield, (recrystallizing from isopropyl alcohol), m.p. 127°-218° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04810713 |
| Source dataset | uspto-grants-1989_03 |
| ORD ID | ord-4182061b7f0e4ada90a7050d1288fa9f |
| Source note | uspto-grants-1989_03 |