HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bis(4-fluorophenyl)(piperidin-4-yl)methanol → HCID 86742793, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bis(4-fluorophenyl)(piperidin-4-yl)methanol | HCID 11208889 | — |
| Reactant | 1-[4-(3-Chloropropoxy)phenyl]ethanone | HCID 12685613 | — |
| Catalyst | Potassium Iodide | HCID 4875 | — |
| Product | HCID 86742793 | HCID 86742793 | 71% |
Reaction Steps
Following the procedure of Example 1, [α,α-bis(p-fluorophenyl)]-4-piperidinemethanol and 1-[4-(3-chloropropoxy)phenyl]ethanone were reacted using potassium iodide catalyst to give the free base of the title compound which when recrystallized from isopropyl alcohol gave the white title compound in 71% yield, m.p. 72°-84° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04810713 |
| Source dataset | uspto-grants-1989_03 |
| ORD ID | ord-87cab2be745c40e1903284d62a387a47 |
| Source note | uspto-grants-1989_03 |