Bis(4-fluorophenyl)(piperidin-4-yl)methanol → HCID 14407099, compound

HRID 1193678Notes

Reaction equation

HRID 1193678 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=2)([CH:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[OH:9])=[CH:4][CH:3]=1.Cl[CH2:24][CH2:25][CH2:26][O:27][C:28]1[CH:33]=[CH:32][C:31]([C:34](=[O:36])[CH3:35])=[CH:30][C:29]=1[CH3:37]>[I-].[K+]>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:16]2[CH:17]=[CH:18][C:19]([F:22])=[CH:20][CH:21]=2)([OH:9])[CH:10]2[CH2:11][CH2:12][N:13]([CH2:24][CH2:25][CH2:26][O:27][C:28]3[CH:33]=[CH:32][C:31]([C:34](=[O:36])[CH3:35])=[CH:30][C:29]=3[CH3:37])[CH2:14][CH2:15]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 11208889Bis(4-fluorophenyl)(piperidin-4-yl)methanolHCID 144071751-[4-(3-Chloropropoxy)-3-methylphenyl]ethanone

Product 1

HCID 14407099HCID 14407099, compoundYield 76%

Reagents, catalysts & solvents 1

HCID 4875Potassium IodideCatalyst

Procedure

Following the procedure of Example 1, [α,α-bis(p-fluorophenyl)]-4-piperidinemethanol and 1-[4-(3-chloropropoxy)-3-methylphenyl]ethanone were reacted using potassium iodide catalyst to give the white title compound (recrystallizing from isopropyl alcohol) in 76% yield, m.p. 116°-117° C.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-9333e6b9246144d79f1fdab7e04db030
Source dataset
uspto-grants-1989_03
Patent number
US04810713

Reaction notes

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