HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → HCID 70393202, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | 4-[Bis(4-fluorophenyl)methyl]piperidine | HCID 13250544 | — |
| Reactant | Ethyl 4-(3-chloropropoxy)benzoate | HCID 18348522 | — |
| Catalyst | Potassium Iodide | HCID 4875 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 70393202 | HCID 70393202 | 20% |
Reaction Steps
Following the procedure of Example 14, 4-[bis(4-fluorophenyl)methyl]piperidine and 4-(3-chloropropoxy)benzoic acid ethyl ester were reacted using potassium iodide as catalyst to give the free base which was reacted with hydrogen bromide in glacial acetic acid. The oil was stripped to dryness and the solid obtained was recrystallized from isopropyl alcohol-diethyl ether to give the white salt in 20% yield, m.p. 142°-144° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04810713 |
| Source dataset | uspto-grants-1989_03 |
| ORD ID | ord-e5532163dd65492fbb0e6bb3841cc11c |
| Source note | uspto-grants-1989_03 |