HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → HCID 14407124, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Bis(4-fluorophenyl)(piperidin-4-yl)methanol | HCID 11208889 | — |
| Reactant | 1-[4-[(5-Chloropentyl)oxy]-3-methoxyphenyl]ethanone | HCID 14407177 | — |
| Catalyst | Potassium Iodide | HCID 4875 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | HCID 14407124 | HCID 14407124 | 65% |
Reaction Steps
Following the procedurre of Example 1 and utilizing potassium iodide catalyst, a mixture of 3.0 g (0.01 mole) of α,α-bis(p-fluorophenyl)-4-piperidinemethanol, 2.7 g (0.01 mole) of 1-[4-(5-chloropentoxy)-3-methoxyphenyl]ethanone and sodium carbonate in butanol, the title compound was prepared in 65% yield as white solid after recrystallization from isopropyl alcohol, m.p. 117.5°-118.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04810713 |
| Source dataset | uspto-grants-1989_03 |
| ORD ID | ord-89bcc5efd52d430fa0acfa517b97b43d |
| Source note | uspto-grants-1989_03 |