HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Butanol → HCID 23036275, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Butanol | HCID 263 | — |
| Reactant | Oxalic Acid | HCID 971 | — |
| Reactant | 4-(3-Chloropropoxy)-3-methoxyacetophenone | HCID 7314264 | — |
| Reactant | HCID 14407163 | HCID 14407163 | — |
| Catalyst | Potassium Iodide | HCID 4875 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | HCID 23036275 | HCID 23036275 | 68.9% |
Reaction Steps
A solution of 4.42 g (0.0164 mole) of 4-[(4-fluorophenyl)phenylmethyl]piperidine and 4.11 g (0.0170 mole) of 1-[4-(3-chloropropoxy)-3-methoxyphenyl]ethanone, 0.01 g of potassium iodide and 1-butanol was refluxed for 18 hr. The solvent was removed in vacuo, and the residue was partitioned between methylene chloride and dilute sodium hydroxide. The solvent was removed in vacuo to give an oil. A solution of the oil in methanol was treated with an equivalent of oxalic acid, ethyl ether was added, and 6.39 g (68.9%) of white crystalline solid, m.p. 161°-163° C. was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04810713 |
| Source dataset | uspto-grants-1989_03 |
| ORD ID | ord-4a92052de0084adba82818ec9ce3a8fa |
| Source note | uspto-grants-1989_03 |