HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Iodide → HCID 86742794, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Bis(4-fluorophenyl)(piperidin-4-yl)methanol | HCID 11208889 | — |
| Reactant | Methyl 4-(3-chloropropoxy)-3-methoxybenzoate | HCID 14407173 | — |
| Catalyst | Potassium Iodide | HCID 4875 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | HCID 86742794 | HCID 86742794 | 53% |
Reaction Steps
Following the procedure of Example 1 and utilizing potassium iodide catalyst and substituting dimethylformamide for butanol, a mixture of 5.4 g (0.021 mole) of 4-(3-chloropropoxy)-3-methoxybenzoic acid methyl ester, 6.0 g (0.02 mole) of [α,α-bis(p-fluorophenyl)]-4-piperidinemethanol, 7.4 g (0.07 mole) of anhydrous sodium carbonate and 0.3 g of potassium iodide in 150 ml of dimethylformamide was reacted to give 5.7 g (53%) of white solid, m.p. 131°-132.5° C. after recrystallization from isopropyl alcohol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04810713 |
| Source dataset | uspto-grants-1989_03 |
| ORD ID | ord-306e23c9871c48aba0a4c167c4ff20cb |
| Source note | uspto-grants-1989_03 |