1-Butanol → HCID 23036370, compound

Participants

Reaction Steps

A mixture of 6.10 g (0.02125 mole) of 4-[bis(4-fluorophenyl)methyl]piperidine and 4.53 g (0.02125 mole) of 4-(3-chloropropoxy)benzamide in 350 ml of 1-butanol containing potassium carbonate (5.53 g, 0.02125 mole) and potassium iodide (0.2 g) was heated overnight at gentle reflux. The reaction was filtered and stripped to dryness. The residue obtained was dissolved in chloroform and extracted with water. The chloroform layer was dried, filtered, and solvent removed to give an oil. This material was converted to the fumarate salt and recrystallized from methanoldiethyl ether. The white crystalline solid obtained was dried in vacuo overnight at 65° C. A yield of 5.47 g (40.3%) of white crystalline product was obtained, m.p. 193°-194° C.

Provenance & Evidence