Sodium Carbonate → HCID 23036336, compound

HRID 1193701Notes

Reaction equation

HRID 1193701 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=2)([CH:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[OH:9])=[CH:4][CH:3]=1.Cl[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][O:30][C:31]1[CH:36]=[CH:35][C:34]([C:37](=[O:39])[CH3:38])=[CH:33][C:32]=1[O:40][CH3:41].C(=O)([O-])[O-].[Na+].[Na+]>[I-].[K+].C(O)CCC>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:16]2[CH:17]=[CH:18][C:19]([F:22])=[CH:20][CH:21]=2)([OH:9])[CH:10]2[CH2:11][CH2:12][N:13]([CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][O:30][C:31]3[CH:36]=[CH:35][C:34]([C:37](=[O:39])[CH3:38])=[CH:33][C:32]=3[O:40][CH3:41])[CH2:14][CH2:15]2)=[CH:4][CH:3]=1

Participants

6

Reactant 3

HCID 10340Sodium CarbonateHCID 11208889Bis(4-fluorophenyl)(piperidin-4-yl)methanolHCID 14407180HCID 14407180, compound

Product 1

HCID 23036336HCID 23036336, compound

Reagents, catalysts & solvents 2

HCID 4875Potassium IodideCatalystHCID 2631-ButanolSolvent

Procedure

Following the procedure of Example 1 and utilizing potassium iodide catalyst, a mixture of [α,α-bis(p-fluorophenyl)]-4-piperidinemethanol and 1-[4-(6-chlorohexoxy)-3-methoxyphenyl]ethanone and sodium carbonate in butanol, the title compound is prepared.

Sources & evidence

ORD record
ord-f5cd4efd095f41d696e613b9d8ec4645
Source dataset
uspto-grants-1989_03
Patent number
US04810713

Reaction notes

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