Bis(4-fluorophenyl)(piperidin-4-yl)methanol → HCID 23036333, compound

HRID 1193705Notes

Reaction equation

HRID 1193705 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=2)([CH:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[OH:9])=[CH:4][CH:3]=1.Br[CH2:24][CH2:25][CH2:26][O:27][C:28]1[CH:33]=[CH:32][C:31]([NH:34][C:35]([NH:37][CH3:38])=[O:36])=[CH:30][CH:29]=1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:16]2[CH:17]=[CH:18][C:19]([F:22])=[CH:20][CH:21]=2)([OH:9])[CH:10]2[CH2:11][CH2:12][N:13]([CH2:24][CH2:25][CH2:26][O:27][C:28]3[CH:33]=[CH:32][C:31]([NH:34][C:35]([NH:37][CH3:38])=[O:36])=[CH:30][CH:29]=3)[CH2:14][CH2:15]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 11208889Bis(4-fluorophenyl)(piperidin-4-yl)methanolHCID 23036285HCID 23036285, compound

Product 1

HCID 23036333HCID 23036333, compound

Procedure

Following the procedure of Example 1, [α,α-bis(p-fluorophenyl) ]-4-piperidinemethanol and N-[4-(3-bromopropoxy)phenyl]-N'-methylurea are reacted to give the title compound.

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-8684da7c801c441c80b3e3b2c44bc88b
Source dataset
uspto-grants-1989_03
Patent number
US04810713

Reaction notes

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