참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 1,4-Dioxane | HCID 31275 | — |
| 반응물 | 2(R)-hydroxy-3(R)-[2-(5-bromo-6-methoxy-2-naphthyl)propanoyl]-butanedioic acid | HCID 54359290 | — |
| 생성물 | 5-Bromonaproxen, (S)- | HCID 11529664 | — |
반응 단계
A mixture of pure 2(R)-hydroxy-3(R)-[2-(5-bromo-6-methoxy-2-naphthyl)propanoyl]-butanedioic acid (0.441 g, 1 mmol), 1,4-dioxane (8 ml), and of conc. HCl (8 ml) was heated, under stirring, at 90° C. for 2 hours. The reaction mixture was worked up as described in example 52, to give pure 2(S)-(5-bromo-6-methoxy-2-naphthyl)-propionic acid in 98% enantiomeric excess, determined by HPLC and by 1H-NMR carried out as described in example 57.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US04810819 |
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| 출처 데이터셋 | uspto-grants-1989_03 |
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| ORD ID | ord-c37d3bb7159b44aaad4d5a333e06f58b |
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| 출처 메모 | uspto-grants-1989_03 |
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