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Hydrochloric Acid → 3-Hydroxymethylchrysene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Lithium borohydride | HCID 4148881 | — |
| 反応物 | Ethyl chrysene-3-carboxylate | HCID 15599328 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 3-Hydroxymethylchrysene | HCID 15599327 | 98.3% |
反応手順
A solution of ethyl chrysene-3-carboxylate (19E 17.7 g, 0.059 mol) in 40 mL THF was treated with LiBH4 (Morton Thiokol, Inc.-Alfa Products, PO Box 299, 152 Andover St., Danvers, MA 01923, 2.7 g, 0.12 mol) in three portions then refluxed for 3 days. The reaction mixture was poured into ice and acidified carefully to pH 1 with 1N HCl. The precipitate was filtered and recrystallized from THF/hexane to afford 14.98 g (98%) of 3-chrysenemethanol mp 187°-189°, (C, H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04810727 |
| 出典データセット | uspto-grants-1989_03 |
| ORD ID | ord-1d648ac149284adfa7963c728af2b900 |
| 出典メモ | uspto-grants-1989_03 |