HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-Hydroxymethylchrysene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Lithium borohydride | HCID 4148881 | — |
| Reactant | Ethyl chrysene-2-carboxylate | HCID 15599324 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Hydroxymethylchrysene | HCID 15599323 | 95% |
Reaction Steps
Ethyl chrysene-2-carboxylate (20B, 10.1 g, 0.034 mol) in THF (500 mL) was treated with LiBH4 (Alfa, 4×0.5 g, 0.092 mol) under gentle reflux for 4 days. The reaction mixture was poured into ice and acidified carefully to pH 1 with 1M HCl. The precipitate was filtered and recrystallized from THF/hexane to afford 8.32 g (95%) of 2-chrysenemethanol mp 261°-262°, (C, H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04810727 |
| Source dataset | uspto-grants-1989_03 |
| ORD ID | ord-1a7ffb5e3341463dbaa938a6cd74b868 |
| Source note | uspto-grants-1989_03 |