Ammonia → 6-Hydroxyquinoline-5-carboxamide

HRID 1193773Notes

Reaction equation

HRID 1193773 reaction equation
C[O:2][C:3]([C:5]1[C:6]2[CH:7]=[CH:8][CH:9]=[N:10][C:11]=2[CH:12]=[CH:13][C:14]=1[OH:15])=O.[NH3:16]>>[OH:15][C:14]1[CH:13]=[CH:12][C:11]2[N:10]=[CH:9][CH:8]=[CH:7][C:6]=2[C:5]=1[C:3]([NH2:16])=[O:2]

Participants

3

Reactant 2

HCID 222Ammonia2×HCID 19077292Methyl 6-hydroxyquinoline-5-carboxylate

Product 1

HCID 212714806-Hydroxyquinoline-5-carboxamide

Procedure

6-Hydroxy-5-quinolinecarboxylic acid methyl ester is reacted with excess ammonia in a steel bomb for 12-18 hr. The excess ammonia is allowed to evaporate and the residue is crystallized from a suitable solvent to give the title compound.

Workup

  1. customto evaporate
  2. customthe residue is crystallized from a suitable solvent

Sources & evidence

ORD record
ord-1f1794ec295444cf871a22b62e3a7491
Source dataset
uspto-grants-1989_03
Patent number
US04810795

Reaction notes

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