Dimethylamine → HCID 13726338、化合物

HRID 1193819ノート

反応式

HRID 1193819 の反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:11][CH:10]([CH2:12][CH2:13]Cl)[CH2:9][N:8]([CH3:15])[C:7](=[S:16])[C:6]=2[CH:17]=1.[CH3:18][NH:19][CH3:20].[C:21]([OH:26])(=[O:25])[C:22]([OH:24])=[O:23]>C(O)C.C(O)(C)C>[OH2:11].[C:21]([OH:26])(=[O:25])[C:22]([OH:24])=[O:23].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:11][CH:10]([CH2:12][CH2:13][N:19]([CH3:20])[CH3:18])[CH2:9][N:8]([CH3:15])[C:7](=[S:16])[C:6]=2[CH:17]=1

参加物

6

反応物 3

HCID 674DimethylamineHCID 971Oxalic AcidHCID 137263017-Chloro-2-(2-chloroethyl)-2,3-dihydro-4-methyl-1,4-benzoxazepine-5(4H)-thione

生成物 1

HCID 13726338HCID 13726338、化合物

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 3776Isopropanol溶媒

実験手順

To a solution of 8.0 g (0.027 mole) of 7-chloro-2-(2-chloroethyl)-2,3-dihydro-4-methyl-1,4-benzoxazepine-5(4H)-thione in 50 ml of absolute ethanol was added 6 ml (0.054 mole) of 40% aqueous solution of dimethylamine. The solution was heated in a steel bomb at 90° C. for 14 hr. The ethanol was removed under reduced pressure and the residue was partitioned between chloroform and aqueous sodium hydroxide. The chloroform layer was concentrated to give a viscous yellow oil. The oil was dissolved in isopropyl alcohol and reacted with oxalic acid. The oxalate salt immediately precipitated. The mixture was heated and a small amount of water was added to dissolve the salt. A white crystalline powder was obtained, m.p. 150°-151° C.

後処理

  1. customThe ethanol was removed under reduced pressure
  2. customthe residue was partitioned between chloroform and aqueous sodium hydroxide
  3. concentrationThe chloroform layer was concentrated
  4. customto give a viscous yellow oil
  5. customThe oxalate salt immediately precipitated
  6. temperatureThe mixture was heated
  7. additiona small amount of water was added
  8. dissolutionto dissolve the salt
  9. customA white crystalline powder was obtained

出典と根拠

ORDレコード
ord-fdd8e0ac893f419c8408ca151fef0f8f
出典データセット
uspto-grants-1989_03
特許番号
US04810795

反応ノート

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