Propargyl alcohol → HCID 21270763, compound

HRID 1193873Notes

Reaction equation

HRID 1193873 reaction equation
[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([N:15]2[C:20](=[O:21])[CH:19]=[C:18]([C:22]([F:28])([F:27])[C:23]([F:26])([F:25])[F:24])[N:17]=[C:16]2Cl)=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:9])[CH3:8])=[O:5].[CH2:30]([OH:33])[C:31]#[CH:32]>N1C=CC=CC=1>[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([N:15]2[C:20](=[O:21])[CH:19]=[C:18]([C:22]([F:28])([F:27])[C:23]([F:25])([F:26])[F:24])[N:17]=[C:16]2[O:33][CH2:30][C:31]#[CH:32])=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:9])[CH3:8])=[O:5]

Participants

4

Reactant 2

HCID 7859Propargyl alcoholHCID 21270698HCID 21270698, compound

Product 1

HCID 21270763HCID 21270763, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

using isopropyl 2-chloro-5-[2-chloro-6-oxo-4-pentafluoroethyl-1(6H)-pyrimidinyl]-4-fluorobenzoate and propargyl alcohol with pyridine there is obtained isopropyl 2-chloro-4-fluoro-5-[6-oxo-4-pentafluoroethyl-2-(2-propynyloxy)-1(6H)-pyrimidinyl]-benzoate, 1H-NMR (CDCl3, 400 MHz): 7.85 ppm (d,1H), 7.41 ppm (d,1H), 6.71 ppm (s,1H), 5.27 ppm (m,1H), 5.00 ppm (d,2H), 2.53 ppm (t,1H), 1.39 ppm (d,3H), 1.38 ppm (d,3H);

Sources & evidence

ORD record
ord-1ff4491185754c64b22f131c1c8c774c
Source dataset
uspto-grants-1989_03
Patent number
US04812164

Reaction notes

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