HCID 21270725, compound → HCID 21270743, compound

HRID 1193882Notes

Reaction equation

HRID 1193882 reaction equation
[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([N:15]2[C:20](=[O:21])[C:19]([F:22])=[C:18]([C:23]([F:26])([F:25])[F:24])[N:17]=[C:16]2Cl)=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:9])[CH3:8])=[O:5]>N1C=CC=CC=1>[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([N:15]2[C:20](=[O:21])[C:19]([F:22])=[C:18]([C:23]([F:26])([F:25])[F:24])[N:17]=[C:16]2[O:5][CH2:4][C:3]#[CH:2])=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:9])[CH3:8])=[O:5]

Participants

3

Reactant 1

HCID 21270725HCID 21270725, compound

Product 1

HCID 21270743HCID 21270743, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

using isopropyl 2-chloro-5-[2-chloro-5-fluoro-6-oxo-4-trifluoromethyl-1(6H)-pyrimidinyl]-4-fluorobenzoate and propargy alcohol with pyridine there is obtained isopropyl 2-chloro-4-fluoro-5-[5-fluoro-6-oxo-2-(2-propynyloxy)-4-trifluoromethyl-1(6H)-pyrimidinyl]-benzoate, 1H-NMR (CDCl3, 400 MHz): 7.85 ppm (d,1H), 7.43 ppm (d,1H), 5.27 ppm (m,1H), 5.01 ppm (d,2H), 2.54 ppm (t,1H), 1.39 ppm (d,3H), 1.38 ppm (d,3H);

Sources & evidence

ORD record
ord-004776f5f24b468185c6e5368fbc4bc6
Source dataset
uspto-grants-1989_03
Patent number
US04812164

Reaction notes

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