Sodium Methoxide → HCID 21270714, compound

HRID 1193883Notes

Reaction equation

HRID 1193883 reaction equation
[Br:1][C:2]1[C:7]([O:8][CH:9]([CH3:11])[CH3:10])=[CH:6][C:5]([N:12]2[C:17](=[O:18])[CH:16]=[C:15]([C:19]([F:22])([F:21])[F:20])[N:14]=[C:13]2Cl)=[C:4]([F:24])[CH:3]=1.[CH3:25][O-:26].[Na+]>CO>[Br:1][C:2]1[C:7]([O:8][CH:9]([CH3:11])[CH3:10])=[CH:6][C:5]([N:12]2[C:17](=[O:18])[CH:16]=[C:15]([C:19]([F:22])([F:21])[F:20])[N:14]=[C:13]2[O:26][CH3:25])=[C:4]([F:24])[CH:3]=1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 21270795HCID 21270795, compound

Product 1

HCID 21270714HCID 21270714, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

using 1-(4-bromo-2-fluoro-5-isopropoxyphenyl)-2-chloro-4-trifluoromethyl-6(1H)-pyrimidinone and sodium methylate in methanol there is obtained 1-(4-bromo-2-fluoro-5-isopropoxyphenyl)-2-methoxy-4-trifluoromethyl-6(1H)-pyrimidinone, m.p. 137° C.;

Sources & evidence

ORD record
ord-de4f1d6571b14670accca7937a4e9d39
Source dataset
uspto-grants-1989_03
Patent number
US04812164

Reaction notes

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