Pyridine → HCID 21270738, compound

HRID 1193885Notes

Reaction equation

[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([N:15]2[C:20](=[O:21])[C:19]([F:22])=[C:18]([C:23]([F:29])([F:28])[C:24]([F:27])([F:26])[F:25])[N:17]=[C:16]2Cl)=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:9])[CH3:8])=[O:5].N1C=CC=CC=1.[CH2:37]([OH:40])[C:38]#[CH:39]>>[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([N:15]2[C:20](=[O:21])[C:19]([F:22])=[C:18]([C:23]([F:29])([F:28])[C:24]([F:26])([F:27])[F:25])[N:17]=[C:16]2[O:40][CH2:37][C:38]#[CH:39])=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:8])[CH3:9])=[O:5]

Participants

Reactant 3

HCID 1049Pyridine

HCID 7859Propargyl alcohol

HCID 21270766HCID 21270766, compound

Product 1

HCID 21270738HCID 21270738, compound

Procedure

using isopropyl 2-chloro-5-[2-chloro-5-fluoro-6 -oxo-4-pentafluoroethyl-1(6H)-pyrimidinyl]-4-fluorobenzoate and pyridine in propargyl alcohol there is obtained isopropyl 2-chloro-5-[5-fluoro-6-oxo-4 -pentafluoroethyl-2-(2-propynyloxy)-1(6H)-pyrimidinyl]-4-fluorobenzoate, 1H-NMR (CDCl3, 400 MHz): 7.86 ppm (d,1H), 7.43 ppm (d,1H), 5.27 ppm (m,1H), 4.97 ppm (d,2H), 2.53 ppm (t,1H), 1.39 ppm (d,3H), 1.38 ppm (d,3H);

Sources & evidence

ORD record: ord-6b4e777237d24da3b8bb6ea1aac931cc
Source dataset: uspto-grants-1989_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04812164

Reaction notes

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