Sodium Methoxide → 1-(4-chloro-2-fluoro-5-isopropoxyphenyl)-5-fluoro-2-methoxy-4-trifluoromethyl-6(1H)-pyrimidinone

HRID 1193886Notes

Reaction equation

HRID 1193886 reaction equation
Cl[C:2]1[N:3]([C:14]2[CH:19]=[C:18]([O:20][CH:21]([CH3:23])[CH3:22])[C:17]([Cl:24])=[CH:16][C:15]=2[F:25])[C:4](=[O:13])[C:5]([F:12])=[C:6]([C:8]([F:11])([F:10])[F:9])[N:7]=1.[CH3:26][O-:27].[Na+]>CO>[Cl:24][C:17]1[C:18]([O:20][CH:21]([CH3:23])[CH3:22])=[CH:19][C:14]([N:3]2[C:4](=[O:13])[C:5]([F:12])=[C:6]([C:8]([F:11])([F:10])[F:9])[N:7]=[C:2]2[O:27][CH3:26])=[C:15]([F:25])[CH:16]=1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 212707052-chloro-1-(4-chloro-2-fluoro-5-isopropoxyphenyl)-5-fluoro-4-trifluoromethyl-6(1H)-pyrimidinone

Product 1

HCID 212707511-(4-chloro-2-fluoro-5-isopropoxyphenyl)-5-fluoro-2-methoxy-4-trifluoromethyl-6(1H)-pyrimidinone

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

using 2-chloro-1-(4-chloro-2-fluoro-5 -isopropoxyphenyl)-5-fluoro-4-trifluoromethyl-6(1H)-pyrimidinone and sodium methylate in methanol there is obtained 1-(4-chloro-2-fluoro-5-isopropoxyphenyl)-5 -fluoro-2-methoxy-4-trifluoromethyl-6(1H)-pyrimidinone, m.p. 144°-146° C.;

Sources & evidence

ORD record
ord-f448d17de01440109b4d390672988623
Source dataset
uspto-grants-1989_03
Patent number
US04812164

Reaction notes

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