Dimethyl Sulfate → HCID 21270710, compound

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Reaction Steps

A mixture of 9.2 g of crude isopropyl 2-chloro-5-[3,6-dihydro-2,6-dioxo-5-fluoro-4-pentafluoroethyl -1(2H) -pyrimidinyl]-4-fluorobenzoate, 3.36 g of sodium bicarbonate and 3.78 g of dimethyl sulphate in 50 ml of anhydrous acetone is heated to reflux temperature for 3 hours. After cooling the solid constituents are filtered off under suction and the filtrate is evaporated to dryness under reduced pressure. The residue is separated by chromatography on a silica gel column using n-hexane/diethyl ether (2:1). There is obtained isopropyl 2-chloro-4-fluoro-5-[5-fluoro-2-methoxy-6-oxo-4-pentafluoroethyl -1(6H)-pyrimidinyl]-benzoate, m.p. 75°-77° C.

Provenance & Evidence