2-Bromopropane → ethyl 2-chloro-5-(4,5,6,7-tetrahydro-2-isopropoxy-4-oxo-3H-cyclopenta[d]pyrimidin-3-yl)-benzoate

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Reaction Steps

using ethyl 2-chloro-5-(1,2,4,5,6,7-hexahydro-2,4-dioxo-3H-cyclopenta[d]pyrimidin-3-yl)-benzoate with sodium hydride and isopropyl bromide in hexamethyl-phosphoric acid triamide there is obtained ethyl 2-chloro-5-(4,5,6,7-tetrahydro-2-isopropoxy-4-oxo-3H -cyclopenta[d]pyrimidin-3-yl)-benzoate. 1H-NMR (CDCl3, 400 MHz): 7.69 ppm (d,1H), 7.54 ppm (d,1H), 7.23 ppm (q,1H), 5.30 ppm (m,1H), 4.38 ppm (q,2H), 2.79 ppm (m,4H). 2.09 ppm (m,2H), 1.38 ppm (t,3H), 1.22 ppm (d,6H).

Provenance & Evidence