Pyridine → HCID 54403325, compound

HRID 1193895Notes

Reaction equation

HRID 1193895 reaction equation
[Cl:1][C:2]1[C:7]([OH:8])=[CH:6][C:5]([N:9]2[C:14](=[O:15])[CH:13]=[C:12]([C:16]([F:19])([F:18])[F:17])[N:11]=[C:10]2[O:20][CH3:21])=[C:4]([F:22])[CH:3]=1.[C:23](Cl)(=[O:25])[CH3:24].N1C=CC=CC=1>C(Cl)Cl>[C:23]([O:8][C:7]1[CH:6]=[C:5]([N:9]2[C:14](=[O:15])[CH:13]=[C:12]([C:16]([F:18])([F:17])[F:19])[N:11]=[C:10]2[O:20][CH3:21])[C:4]([F:22])=[CH:3][C:2]=1[Cl:1])(=[O:25])[CH3:24]

Participants

5

Reactant 3

HCID 1049PyridineHCID 6367Acetyl chlorideHCID 21270742HCID 21270742, compound

Product 1

HCID 54403325HCID 54403325, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

using 1-(4-chloro-2-fluoro-5-hydroxyphenyl)-2-methoxy-4-trifluoromethyl-6(1H)-pyrimidinone and acetyl chloride with pyridine in methylene chloride there is obtained 2-chloro-4-fluoro-5-[2-methoxy -6-oxo-4-trifluoromethyl-1(6H)-pyrimidinyl]-phenyl acetate, m.p. 110°-112° C.;

Sources & evidence

ORD record
ord-0e816ff2af1c4580ac1c1e460ef1e162
Source dataset
uspto-grants-1989_03
Patent number
US04812164

Reaction notes

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