Chloromethyl Methyl Ether → HCID 54425953, compound

HRID 1193896Notes

Reaction equation

HRID 1193896 reaction equation
[Cl:1][C:2]1[C:7]([OH:8])=[CH:6][C:5]([N:9]2[C:14](=[O:15])[CH:13]=[C:12]([C:16]([F:19])([F:18])[F:17])[N:11]=[C:10]2[O:20][CH3:21])=[C:4]([F:22])[CH:3]=1.[CH3:23][O:24][CH2:25]Cl.C(=O)([O-])[O-].[Na+].[Na+]>CC(C)=O>[Cl:1][C:2]1[C:7]([O:8][CH2:23][O:24][CH3:25])=[CH:6][C:5]([N:9]2[C:14](=[O:15])[CH:13]=[C:12]([C:16]([F:18])([F:17])[F:19])[N:11]=[C:10]2[O:20][CH3:21])=[C:4]([F:22])[CH:3]=1

Participants

5

Reactant 3

HCID 7864Chloromethyl Methyl EtherHCID 10340Sodium CarbonateHCID 21270742HCID 21270742, compound

Product 1

HCID 54425953HCID 54425953, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

using 1-(4-chloro-2-fluoro-5-hydroxyphenyl)-2-methoxy-4-trifluoromethyl-6(1H)-pyrimidinone and chlorodimethyl ether with sodium carbonate in acetone there is obtained 1-[4-chloro-2-fluoro-5-(methoxymethoxy) -phenyl]-2-methoxy-4-trifluoromethyl-6(1H)-pyrimidinone, m.p. 97°-98° C.;

Sources & evidence

ORD record
ord-409368ec619c4a4c82ef845e814f96ba
Source dataset
uspto-grants-1989_03
Patent number
US04812164

Reaction notes

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