Dimethyl Sulfate → HCID 21270791, compound

HRID 1193900Notes

Reaction equation

HRID 1193900 reaction equation
[Cl:1][C:2]1[C:7]([OH:8])=[CH:6][C:5]([N:9]2[C:14](=[O:15])[CH:13]=[C:12]([C:16]([F:22])([F:21])[C:17]([F:20])([F:19])[F:18])[N:11]=[C:10]2[O:23][CH2:24][CH3:25])=[C:4]([F:26])[CH:3]=1.S(OC)(O[CH3:31])(=O)=O.C(=O)([O-])[O-].[Na+].[Na+]>CC(C)=O>[CH2:24]([O:23][C:10]1[N:9]([C:5]2[CH:6]=[C:7]([O:8][CH3:31])[C:2]([Cl:1])=[CH:3][C:4]=2[F:26])[C:14](=[O:15])[CH:13]=[C:12]([C:16]([F:21])([F:22])[C:17]([F:20])([F:18])[F:19])[N:11]=1)[CH3:25]

Participants

5

Reactant 3

HCID 6497Dimethyl SulfateHCID 10340Sodium CarbonateHCID 21270730HCID 21270730, compound

Product 1

HCID 21270791HCID 21270791, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

using 1-(4-chloro-2-fluoro-5-hydroxyphenyl)-2-ethoxy-4-pentafluoroethyl-6(1H)-pyrimidinone and dimethyl sulphate with sodium carbonate in acetone there is obtained 2-ethoxy-1-(4-chloro-2-fluoro-5 -methoxyphenyl)-4-pentafluoroethyl-6(1H)-pyrimidinone, 1H-NMR (CDCl3, 400 MHz): 7.33 ppm (d,1H), 6.79 ppm (d,1H), 6.65 ppm (s,1H), 4.48 ppm (m,2H), 3.89 ppm (s,3H), 1.29 ppm (t,3H);

Sources & evidence

ORD record
ord-afe37d5888944c698cf4c4db5fa9ad54
Source dataset
uspto-grants-1989_03
Patent number
US04812164

Reaction notes

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