Pyridine → HCID 54097313, compound

HRID 1193902Notes

Reaction equation

HRID 1193902 reaction equation
[CH2:1]([O:3][C:4]1[N:5]([C:15]2[CH:20]=[C:19]([OH:21])[C:18]([Cl:22])=[CH:17][C:16]=2[F:23])[C:6](=[O:14])[CH:7]=[C:8]([C:10]([F:13])([F:12])[F:11])[N:9]=1)[CH3:2].Cl[C:25]([O:27][CH2:28][CH2:29][CH2:30][CH3:31])=[O:26].N1C=CC=CC=1>C(OCC)C>[C:25](=[O:26])([O:21][C:19]1[CH:20]=[C:15]([N:5]2[C:6](=[O:14])[CH:7]=[C:8]([C:10]([F:13])([F:11])[F:12])[N:9]=[C:4]2[O:3][CH2:1][CH3:2])[C:16]([F:23])=[CH:17][C:18]=1[Cl:22])[O:27][CH2:28][CH2:29][CH2:30][CH3:31]

Participants

5

Reactant 3

HCID 1049PyridineHCID 61140Butyl chloroformateHCID 21270727HCID 21270727, compound

Product 1

HCID 54097313HCID 54097313, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

using 2-ethoxy-1-(4-chloro-2-fluoro-5 -hydroxyphenyl)-4-trifluoromethyl-6(1H)-pyrimidinone and n-butyl chloroformate with pyridine in diethyl ether there is obtained n-butyl {5-[2-ethoxy-6-oxo-4 -trifluoromethyl-1(6H) -pyrimidinyl]-2-chloro-4-fluorophenyl} carbonate, m.p. 100°-102° C.;

Sources & evidence

ORD record
ord-a2d530fe8bb54ced9e671fba493763d6
Source dataset
uspto-grants-1989_03
Patent number
US04812164

Reaction notes

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