Propargyl bromide → HCID 21270757, compound

HRID 1193904Notes

Reaction equation

HRID 1193904 reaction equation
[CH2:1]([O:3][C:4]1[N:5]([C:15]2[CH:20]=[C:19]([OH:21])[C:18]([Cl:22])=[CH:17][C:16]=2[F:23])[C:6](=[O:14])[CH:7]=[C:8]([C:10]([F:13])([F:12])[F:11])[N:9]=1)[CH3:2].[CH2:24](Br)[C:25]#[CH:26].C(=O)([O-])[O-].[Na+].[Na+]>CC(C)=O>[CH2:1]([O:3][C:4]1[N:5]([C:15]2[CH:20]=[C:19]([O:21][CH2:26][C:25]#[CH:24])[C:18]([Cl:22])=[CH:17][C:16]=2[F:23])[C:6](=[O:14])[CH:7]=[C:8]([C:10]([F:13])([F:11])[F:12])[N:9]=1)[CH3:2]

Participants

5

Reactant 3

HCID 7842Propargyl bromideHCID 10340Sodium CarbonateHCID 21270727HCID 21270727, compound

Product 1

HCID 21270757HCID 21270757, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

using 2-ethoxy-1-(4-chloro-2-fluoro-5 -hydroxyphenyl) -4-trifluoromethyl-6(1H)-pyrimidinone and propargyl bromide with sodium carbonate in acetone there is obtained 2-ethoxy-1-[4-chloro-2-fluoro-5 -(2-propynyloxy)-phenyl]-4-trifluoromethyl-6(1H)-pyrimidinone, 1H-NMR (CDCl3, 400 MHz): 7.34 ppm (d,1H), 6.97 ppm (d,1H), 6.60 ppm (s,1H), 4.76 ppm (m,2H), 4.50 ppm (m,2H), 2.57 ppm (t,1H), 1.29 ppm (t,3H);

Sources & evidence

ORD record
ord-d85a3e15647c489a9d159110fd83b5c8
Source dataset
uspto-grants-1989_03
Patent number
US04812164

Reaction notes

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