Propargyl bromide → HCID 21270770, compound

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Reaction Steps

using 1-(4-chloro-2-fluoro-5-hydroxyphenyl)-4-pentafluoroethyl-2-(n-propoxy)-6(1H)-pyrimidinone and propargyl bromide with sodium carbonate in acetone there is obtained 1-[4-chloro-2-fluoro-5-(2-propynyloxy)-phenyl]-4-pentafluoroethyl-2-(n-propoxy)-6(1H)-pyrimidinone, 1H-NMR (CDCl3, 400 MHz): 7.34 ppm (d,1H), 6.98 ppm (d,1H), 6.65 ppm (s,1H), 4.76 ppm (m,2H), 4.36 ppm (m,2H), 2.56 ppm (t,1H), 1.67 ppm (m,2H), 0.85 ppm (t,3H);

Provenance & Evidence