HuagongsheHuagongshe Chemistry Print Report · For research reference only
Propargyl bromide → 1-[4-chloro-2-fluoro-5-(2-propynyloxy)-phenyl]-2-propoxy-4-trifluoromethyl-6(1H)-pyrimidinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Propargyl bromide | HCID 7842 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 1-(4-chloro-2-fluoro-5-hydroxyphenyl)-2-propoxy-4-trifluoromethyl-6(1H)-pyrimidinone | HCID 21270716 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 1-[4-chloro-2-fluoro-5-(2-propynyloxy)-phenyl]-2-propoxy-4-trifluoromethyl-6(1H)-pyrimidinone | HCID 53981225 | — |
Reaction Steps
using 1-(4-chloro-2-fluoro-5-hydroxyphenyl)-2-propoxy-4-trifluoromethyl-6(1H)-pyrimidinone and propargyl bromide with sodium carbonate in acetone there is obtained 1-[4-chloro-2-fluoro-5-(2-propynyloxy) -phenyl]-2-propoxy-4-trifluoromethyl-6(1H)-pyrimidinone, 1H-NMR (CDCl3, 400 MHz): 7.34 ppm (d,1H), 6.98 ppm (d,1H), 6.60 ppm (s,1H), 4.76 ppm (m,2H), 4.39 ppm (m,2H), 2.56 ppm (t,1H), 1.67 ppm (m,2H), 0.85 ppm (t,3H);
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04812164 |
| Source dataset | uspto-grants-1989_03 |
| ORD ID | ord-66c994fe24fb4176bcffe012f4759164 |
| Source note | uspto-grants-1989_03 |