Dicyclohexylcarbodiimide → HCID 21270712, compound

Participants

Reaction Steps

0.74 g of N,N'-dicyclohexylcarbodiimide is added while stirring at room temperature to a solution of 1.60 g of 1-(4-chloro-2-fluoro-5-hydroxyphenyl)-5-fluoro-2-methoxy-4-pentafluoroethyl-6(1H)-pyrimidinone, 0.30 g of 4-pentynoic acid and 0.05 g of 4-pyrrolidino-pyridine in 50 ml of methylene chloride and the mixture is stirred at room temperature for 5 hours. Insoluble constituents are subsequently filtered off under suction and the filtrate is evaporated to dryness. The residue is purified by chromatography on a silica gel column using n-hexane/diethyl ether (3:1) as the eluent. The product is recrystallized from n-hexane/diethyl ether. There is obtained 2-chloro-4-fluoro-5-[5-fluoro-2 -methoxy-6-oxo-4-pentafluoroethyl-1(6H)-pyrimidinyl]-phenyl 4-pentynoate, m.p. 107°-109° C.

Provenance & Evidence