Sulfuric Acid → HCID 21270728, compound

HRID 1193926Notes

Reaction equation

[Cl:1][C:2]1[C:7]([O:8]C(C)C)=[CH:6][C:5]([N:12]2[C:17](=[O:18])[CH:16]=[C:15]([C:19]([F:25])([F:24])[C:20]([F:23])([F:22])[F:21])[N:14]=[C:13]2[O:26][CH2:27][CH2:28][CH3:29])=[C:4]([F:30])[CH:3]=1.S(=O)(=O)(O)O>>[Cl:1][C:2]1[C:7]([OH:8])=[CH:6][C:5]([N:12]2[C:17](=[O:18])[CH:16]=[C:15]([C:19]([F:24])([F:25])[C:20]([F:23])([F:21])[F:22])[N:14]=[C:13]2[O:26][CH2:27][CH2:28][CH3:29])=[C:4]([F:30])[CH:3]=1

Participants

Reactant 2

HCID 1118Sulfuric Acid

HCID 21270713HCID 21270713, compound

Product 1

HCID 21270728HCID 21270728, compound

Procedure

using 1-(4-chloro-2-fluoro-5-isopropoxyphenyl)-4-pentafluoroethyl-2-propoxy-6(1H)-pyrimidinone with concentrated sulphuric acid at 0° C. during 1.5 minutes there is obtained 1-(4-chloro-2-fluoro-5-hydroxyphenyl)-4-pentafluoroethyl-2-propoxy-6(1H)-pyrimidinone, m.p. 109°-111° C.;

Workup

customat 0° C.
customduring 1.5 minutes

Sources & evidence

ORD record: ord-e88a31bbb7004d42b544086003d270df
Source dataset: uspto-grants-1989_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04812164

Reaction notes

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